MPL and Macrothrombocytopenia: For instance, the expression level of Myosin‐9 is increased during megakaryocyte maturation, and Myosin‐9 mutation‐related disease leads to macrothrombocytopenia.[40, 41] Rab6A has been shown to regulate cargo trafficking between the Golgi and the membrane.[42] Myosin‐9 can bind to GTP‐Rab6A after EtOH treatment.[43] Our study revealed that Rab6A/Myosin‐9 regulates MK maturation by promoting the membrane trafficking of c‐Mpl, which deepens our understanding of these previous works and provides novel ideas for the treatment of c‐Mpl‐associated diseases.