Notably, the serum TPO concentration and total expression of c‐Mpl are invariably greater in ITP patients than in healthy controls, which contradicts the presence of TPO/c‐Mpl signal transduction defects in ITP.[32] In our study, we found decreased cell surface expression of c‐Mpl in the MKs of ITP patients and in a murine model, which illustrated that evaluating the membrane location of c‐Mpl in MKs is necessary for treating ITP patients, especially refractory patients. Here, TPO is linked to autoimmune thrombocytopenic purpura.