For instance, the expression level of Myosin‐9 is increased during megakaryocyte maturation, and Myosin‐9 mutation‐related disease leads to macrothrombocytopenia.[40, 41] Rab6A has been shown to regulate cargo trafficking between the Golgi and the membrane.[42] Myosin‐9 can bind to GTP‐Rab6A after EtOH treatment.[43] Our study revealed that Rab6A/Myosin‐9 regulates MK maturation by promoting the membrane trafficking of c‐Mpl, which deepens our understanding of these previous works and provides novel ideas for the treatment of c‐Mpl‐associated diseases. This evidence concerns the gene RAB6A and Macrothrombocytopenia.