To further verify this observation, we measured the membrane density of c‐Mpl using FCM, which showed that the MFI of c‐Mpl was significantly lower in the ITP group compared with the control group, which suggested that defective membrane localization of c‐Mpl is a critical cause of ITP (Figure 1D,E). This evidence concerns the gene MPL and autoimmune thrombocytopenic purpura.