The natural progression of HDV towards liver cirrhosis, the spontaneous clearance of HCV in the absence of specific antiviral treatment, and the excellent response to Bulevirtide and Entecavir therapy—with a notable improvement in ALT and AST values after 4 weeks of treatment and no reported side effects—are the main topics of discussion in relation to the second case, which has HDV dominance. Here, GPT is linked to cirrhosis of liver.