Beyond ubiquitous TP53/BRCA alterations, two emerging OCS selective signals deserve mention: over expression of N myristoyltransferase 1 (NMT1) identified in many ovarian tumors but <5% of high-grade serous controls [33] and focal CCND1 amplification associated with rapid proliferation and chemoresistance [34]. This evidence concerns the gene NMT1 and ovarian neoplasm.