GSDMD and colitis: The expression profile of miRNAs in Bf‐OMVs is assessed, revealing that Bf‐OMVs are enriched with mmu‐miR‐like sRNA, miR‐5119, which targets and inhibits PD‐L1, leading to the suppression of GSDMD‐mediated NET release and promoting the proliferation of intestinal stem cells (ISCs), culminating in the alleviation of colitis.