Cyclosporine A alleviates colitis by inhibiting the formation of NETs via the regulation of the pentose phosphate pathway.[42] Knocking out PAD4 to block NET formation reduces clinical colitis indices, intestinal inflammation, and barrier dysfunction.[43] In this study, we found that Bf‐OMVs significantly inhibit the recruitment of neutrophils from the bone marrow to the periphery and downregulate neutrophil infiltration in the colon tissues. This evidence concerns the gene PADI4 and colitis.