SERPINF2 and neoplasm: Differing from the lactate tumor growth-promoting effects, free MG, once it is glycated with the extracellular intra-tumoral molecular components, may activate RAGE, the multi-ligand receptor for AGEs, which has been shown to be expressed in both cancer and normal cells [103,104,105,106], and it has been shown that once it is activated, it can inhibit apoptosis [107] and promote tumor growth and metastasis via molecular pathways such as AP-I, NF-kB, PI3K and mTor [60].