Limited communication between APOE– tumor cells and NK, B, and T cells, especially in the CD6- and F11R-driven signaling pathways, was observed by Xiao et al. [39] through the mapping of scRNA-seq data onto spatial coordinates of PTC, which highlights the role of APOE in creating an immunosuppressive microenvironment in the tumor. This evidence concerns the gene APOE and neoplasm.