CEACAM5 and melanoma: In accordance with the CEA-specific CAR T cells, aCSPG4-28ζ-sSF6 CAR T cells were eminently superior to aCSPG4-28ζ-GFP control CAR T cells in melanoma cell elimination upon several rounds of re-stimulation, while no significant differences in CAR T cell expansion or persistence were observed (Figure 4E).