IGHE and peanut allergic reaction: Similarly, Bead-Based Epitope Assay (BBEA)—a highly reliable and sensitive method for detecting epitope-specific antibodies, tested in peanut allergy [112]—showed that epitope-specific IgE is a valuable biomarker for food allergy severity and phenotypes, while IgE/IgG4 quantification provides deeper insights into allergic sensitization.