We also confirmed that the selective JNK3 inhibitor IQ-1S is able to suppress neurodegenerative changes in the OXYS rat retina, and demonstrated that its effects are prevention of the destructive changes in retinal synapses and suppression of JNK3 signaling pathway activity during active progression of AMD signs in OXYS rats. The gene discussed is MAPK10; the disease is age-related macular degeneration.