SHROOM3 and nephrotic syndrome: In a cohort of patients with nephrotic syndrome, glomerular SHROOM3 expression was markedly lower in patients with eGFR < 60 mL/min/1.73 m2 compared to those with eGFR ≥ 60 mL/min/1.73 m2 (Figure S3A) and significantly correlated with eGFR levels (Figure S3B).