Although the link between NF-κB activation and proteinuria in DN remains unclear, studies have demonstrated that NF-κB is activated in multiple renal cell types, including podocytes, in human proteinuric diseases of a different etiology, such as lupus nephritis, minimal change disease, and idiopathic membranous nephropathy [47]. This evidence concerns the gene NFKB1 and lipoid nephrosis.