A deficiency of Arid4a in mice follows a series of clinical conditions that are similar in humans, like defective hematopoiesis, chronic myelomonocytic leukemia (CMML)-like myelodysplastic/myeloproliferative disorder, and its final transformation into acute myeloid leukemia (AML) [30]. The gene discussed is ARID4A; the disease is acute myeloid leukemia.