An autoimmune model of MS, experimental autoimmune encephalomyelitis (EAE), has also supported the autoimmune theory, where EAE can be induced by sensitization with CNS antigens, including myelin oligodendrocyte glycoprotein (MOG) and myelin proteolipid protein (PLP) [13,19,20]. Here, PLP1 is linked to experimental autoimmune encephalomyelitis.