MAPT and Alzheimer disease: All three compounds showed a lower affinity for Aβ (Ki = 1490 nM for GMC-058, 2630 nM for GMC-073, and 226 nM for GMC-098) and tau (Ki= 1320 nM for GMC-058, 248 nM for GMC-073, and 805 nM for GMC-098) in AD brain homogenates.