SAE1 and Premature aging appearance-developmental delay-cardiac arrhythmia syndrome: These proteins include ELOA (elongin-A), GCN1 (GCN1 activator of EIF2AK4, also known as the stalled ribosome sensor GCN1), PPIA (peptidylprolyl isomerase A), RPL13A (ribosomal protein L13a), RPP30 (ribonuclease P/MRP subunit p30), and SAE1 (SUMO1 activating enzyme subunit 1), which were identified in both cellular models of Ogden syndrome and the NAA10-knockdown HeLa cancer model [37,62].