As a KAT, NAA10 acetylates internal lysine residues on various proteins identified in cancer models, including AR, AURKA (Aurora kinase A), CTNNB1 (β-catenin), HSP70 (heat shock protein 70), MLCK (myosin light-chain kinase, also known as MYLK), MSRA (methionine sulfoxide reductase A), NRF2, PGK1 (phosphoglycerate kinase 1), SAMHD1 (SAM domain and HD domain-containing protein 1), and NAA10 itself (Table 1). This evidence concerns the gene SAMHD1 and cancer.