This study demonstrated that the Ogden syndrome-causing NAA10 mutation disrupts the binding of NAA10 and DNMT1 to imprinting control regions of the genome, suggesting that the non-catalytic functions of NAA10 also contribute to the development and pathological phenotypes of NAA10-related syndromes. The gene discussed is NAA10; the disease is Premature aging appearance-developmental delay-cardiac arrhythmia syndrome.