More recently, proteomic analysis of the human epidermoid carcinoma cell line A431 following siRNA knockdown of both NAA10 and NAA15 identified 173 proteins with altered N-terminal acetylation, including GCN1, ALKBH7 (alpha-ketoglutarate-dependent dioxygenase ALKB homolog 7), and TIMM8B (translocase of inner mitochondrial membrane 8 homolog B) [111]. The gene discussed is TIMM8B; the disease is squamous cell carcinoma.