STRAP acts as a scaffold by interacting with various key molecules involved in cell-fate-deciding pathways such as TGF-β, Wnt/ß-Catenin, Notch, etc. STRAP upregulation has been shown to attenuate TGF-β-mediated growth inhibition in lung and colon carcinoma and increase tumorigenesis in xenograft models [5,12]. Here, TGFB1 is linked to colon carcinoma.