MAP3K5 and cancer: STRAP is a potent oncogene, initially identified as an inhibitor of TGF-ß signaling, and plays a critical role in the activation of several tumorigenic and metastatic pathways, including Notch, MEK/ERK, PKB/AKT, ASK1, and Wnt/ß-Catenin signaling, contributing to cancer cell stemness and therapeutic resistance.