The above discussions of in vitro experiments suggest that STRAP regulates various oncogenic signaling pathways, leading to cell growth, migration, invasion, EMT, etc. In support of these observations, in vivo xenograft, allograft, and genetic mouse models have shown that the upregulation of STRAP expression promotes tumor initiation, progression, and metastasis [14,56]. This evidence concerns the gene STRAP and neoplasm.