In addition, CRISPR/Cas12a-based biosensors have shown promise for the detection of lung cancer biomarkers; researchers developed a fan- and dumbbell-shaped probe as a template for crRNA enrichment through rolling circle transcription (RCT) to simultaneously detect human 8-hydroxyguanine DNA glycosidase (hOGG1) and flap endonuclease 1 (FEN1), both of which are closely associated with lung cancer [90]. The gene discussed is FEN1; the disease is lung cancer.