Moreover, the EfaA gene that may play an adhesin role in endocarditis, the GroEL gene involved in the adhesion or invasion of various target cells or tissues, and clpC, clpE, and clpP genes, which are related to stress survival, respond to stress and protect proteins from excessive damage, also were annotated in the whole genome of L. rhamnosus CP-1 [41,42,43,44,45,46,47,48]. Here, HSPD1 is linked to endocarditis.