GPX4 and neoplasm: In contrast, cuproptosis is a novel mode of cell death caused by copper ions leading to a loss of iron‐sulfur cluster (Fe‐S) proteins and aggregation of dihydrolipoamide S‐acetyltransferase (DLAT).[3a] Leveraging copper ions as an anti‐tumor strategy holds significant promise, as they not only modulate the GPX4‐GSH axis but also initiate cellular cuproptosis.