It’s worth noting that O-GlcNAcylation is closely related to multiple aspects of bone remodeling, including osteoblast-osteoclast balance, osteoblast-lipoblast balance and bone immune microenvironment.50-52 Therefore, additional research is necessary to thoroughly assess the influence of Bsp O-GlcNAcylation in combination with other phenotypes, in order to offer a more comprehensive comprehension of osteoporosis. Here, IBSP is linked to osteoporosis.