This study established Mettl7a as a critical epigenetic modulator in ovariectomy (OVX)-induced osteoporosis, demonstrating its capacity to rescue osteogenic potential in mBMSCs through m6A-mediated regulation of Bsp O-GlcNAcylation, thus to alleviated bone loss in osteoporosis mice. This evidence concerns the gene IBSP and osteoporosis.