These include TFE3-rearranged RCC, TFEB-altered RCC, ELOC (elongin-C-mutated; formerly TCEB1)-mutated RCC, Fumarate hydratase–deficient RCC (FHdef-RCC), Hereditary Leiomyomatosis and RCC (HLRCC) syndrome, succinate-dehydrogenase-deficient RCC (SDH), ALK rearranged RCC, Medullary carcinoma (not otherwise specified [NOS]), and SMARCB1-deficient medullary, dedifferentiated, and undifferentiated RCC [10]. The gene discussed is ALK; the disease is renal cell carcinoma.