TET2, a member of the TET (ten‐eleven translocation) family, is known to be a key regulator of DNA demethylation due to its dioxygenase activity.[31] The upregulation of TET2 can effectively promote collagen synthesis and alleviate arthritis.[32] However, the role of TET2 in IVD has not yet been clarified. Here, TET2 is linked to arthritic joint disease.