Downregulated in T. denticola-induced periodontitis (32). Downregulated in the saliva of patients with aggressive periodontitis (88). Upregulated in gingival tissue of chronic periodontitis patients (89). IL-13, a cytokine essential for allergic lung diseases, is regulated by mmu-let-7a-5p (90). Downregulated in bronchial biopsy of severe asthma patients (91). Associated with CRC (92). The gene discussed is IL13; the disease is chronic periodontitis.