Our previous work across multiple heart failure models consistently showed a more pronounced reduction in DWORF protein levels compared to mRNA levels, suggesting that post-transcriptional or post-translational mechanisms play a significant role in regulating DWORF expression (Makarewich et al., 2020, 2018; Morales et al., 2024, 2023; Nelson et al., 2016). This evidence concerns the gene STRIT1 and heart failure.