In this context, engineered herpes simplex virus type 1 (HSV‐1) has been utilized to enhance DDR in glioblastoma (GBM) and glioblastoma stem‐like cells (GSC), demonstrating improved therapeutic outcomes.[31] Inducing DNA damage in tumor cells has proven effective in promoting MICA expression, which subsequently enhances NK cell recognition and cytotoxicity against these cells. The gene discussed is MICA; the disease is neoplasm.