To comprehensively elucidate the molecular mechanisms underlying enhanced DNA damage‐induced apoptosis in multiple myeloma (MM) cells through concurrent inhibition of PIM‐2 and PARP1, we performed RNA sequencing on U266 and RPMI‐8226 cell lines following combined treatment with SMI‐16a and ABT888. The gene discussed is PARP1; the disease is plasma cell myeloma.