IL1R1 and stroke disorder: Furthermore, IL‐1β has been reported to enhance neutrophil mobilization from the bone marrow in conditions like myocardial infarction.[23] Administration of the IL‐1R1 antagonist anakinra similarly reduced leukocyte counts, particularly neutrophils, in patients with stroke.[32] Our findings support these observations by showing significantly increased IL‐1R1 expression in bone marrow neutrophils post‐tMCAO, reinforcing the role of IL‐1β in promoting neutrophil mobilization.