Furthermore, IL‐1β has been reported to enhance neutrophil mobilization from the bone marrow in conditions like myocardial infarction.[23] Administration of the IL‐1R1 antagonist anakinra similarly reduced leukocyte counts, particularly neutrophils, in patients with stroke.[32] Our findings support these observations by showing significantly increased IL‐1R1 expression in bone marrow neutrophils post‐tMCAO, reinforcing the role of IL‐1β in promoting neutrophil mobilization. This evidence concerns the gene IL1B and stroke disorder.