In the context of AP, sirtuins exhibit multiple protective effects: SIRT1 reduces inflammatory cytokine release by inhibiting NF‐κB signaling and suppresses macrophage activation via PPARγ activation; SIRT3 improves mitochondrial antioxidant capacity, mitigates oxidative stress, and regulates autophagy and apoptosis in acinar cells. This evidence concerns the gene SIRT1 and alkaline phosphatase measurement.