CDKN2A and neoplasm: Tax also upregulates histone methyltransferases like EZH2 and DNMT3B, leading to aberrant accumulation of H3K27me3 and hypermethylation of CpG islands at tumor suppressor loci including CDKN2A, TP53, and SOCS1 (Yamagishi et al., 2021;Rosewick et al., 2017;Matsuo et al., 2022).