The first RCT demonstrated no improvement in various parameters of RA activity.118 However, the second trial, involving 120 RA patients, revealed that Flaxseed (30g/day) decreased DAS28, pain severity, and morning stiffness.119 Two meta-analyses assessed the effectiveness of flaxseed on CRP and inflammatory cytokines in adults, the first found no significant decrease in CRP levels,117 while the second revealed a significant reduction in concentrations of CRP and IL-6.120 Black cumin (Nigella sativa) holds significant value in traditional medicine. Here, CRP is linked to rheumatoid arthritis.