HLA-DRB1 and multiple sclerosis: Finally, DRB1* has been associated with multiple sclerosis,31 particularly DRB1*08:04 (OR 3.2), DRB1*11:02 (OR 2.3) in African and European Americans,32 while association with HLA DRB1*15:02:01 (OR 95%) (Pc = 0.002) and DRB1*13:01:01 (OR 95%) (Pc = 1.055 × 10−4) is revealed in Thai patients.33 However, it is now believed that exogenous factors, such as exposure to silica, organic solvents, asbestos, and epoxy resins, play a much important role in the disease appearance than previously thought.34