TNF and rheumatoid arthritis: Moreover, P53 induces cell cycle arrest and inhibits the proliferation of damaged cells by regulating the expression of cell cycle-related genes, including P21, hence contributing to erythrocyte stability (90).P53 mitigates the symptoms of patients with RA by inhibiting pro-inflammatory factor production, including TNF-α, and by modulating the activation, proliferation, and differentiation of T- and B-cells (91).