reported that the synovial membrane of joints in patients with RA contains lipid peroxidation metabolites that can recognize and bind to cell surface receptors, including toll-like receptor 4 (TLR4), thereby altering the properties of the cell membrane, interfering with cell signaling, and exacerbating the pathological process of RA (83). The gene discussed is TLR4; the disease is rheumatoid arthritis.