The results indicate that the expression levels of nine Hub Genes in the Psoriasis and Control groups of the Combined GEO Datasets were highly statistically significant (p < 0.001): POSTN, EPCAM, CD274, CD24, SERPINB3, CXCL13, SMPD3, BIRC5, and RAB27A. Finally, the R package pROC was used to generate ROC curves based on the expression levels of Hub Genes in the Combined GEO Datasets. This evidence concerns the gene SMPD3 and psoriasis.