SMPD3 and psoriasis: The identified DEGs include: CD274 (Programmed Death-Ligand 1, PD-L1), SERPINB3, CD24, RAB27A, RAB27B, BIRC5 (Survivin), CXCL13, SDC4 (Syndecan-4), LGALS3BP (Galectin-3-binding protein), POSTN (Periostin), SMPD3 (Sphingomyelin phosphodiesterase 3), IVL (Involucrin), PLCB4 (Phospholipase C beta 4), EPCAM (Epithelial cell adhesion molecule), FCGBP (Fibrinogen C domain-containing protein 6, Keratinocyte differentiation-associated protein 1), and MYOC (Myocilin). The expression of these genes is closely associated with the pathogenesis of psoriasis.