In addition, Hippo signaling mainly consists of MST1/2, SAV1, MOB1A/B, LATS1/2, YAP, transcriptional coactivator with PDZ-binding motif (TAZ) and transcription enhancement-associated structural domain (TEAD) family of multiple key proteins (164), and importantly the pathway can inhibit tumor development through these components (163). The gene discussed is LATS1; the disease is neoplasm.