The study identified that isoform 1 of the neurogenesis-associated protein ASPM (ASPM-I1) plays a crucial role in SCLC development by stabilizing the Hh transcription factor GLI3 via a unique coding region in exon 3 and activating the Wnt-DVL3-β-catenin signaling pathway, which sustains the transcription of the Hh pathway regulator Smoothened (SMO) (73). This evidence concerns the gene SMO and small cell lung carcinoma.