SIK1 and SIK3 are two tumor suppressor kinases of the AMPK family, and it has been found that in Kras-driven LC, the results of LKB1 deletion and SIK1/SIK3 deletion in regulating gene expression are highly overlapping and LKB1 deletion seems to activate the IL6/JAK/STAT pathway, which gives us a new direction for the treatment of LKB1 mutant LC (213). This evidence concerns the gene SIK3 and laryngotracheoesophageal cleft.