identified specific lysine succinylation sites on CS that are regulated by SIRT5 (44).In addition, SIRT5 deficiency has been associated with enhanced succinylation of CS in both colorectal tumor model and subarachnoid hemorrhage model (23, 45).These findings demonstrate that SIRT5 directly interacts with CS, and its downregulation results in hyper-succinylation of CS. This evidence concerns the gene SIRT5 and colorectal neoplasm.