One of the most prominent inflammatory changes in the BMECs in MS is the upregulation of the selectin family of endothelial adhesion molecules; cell adhesion molecules such as ICAM-1, VCAM-1, MCAM, and ALCAM; chemokines on the luminal surface of brain endothelial cells; and the upregulation of class II MHC molecules (134), which contribute to the migration of immune cells into the brain. The gene discussed is VCAM1; the disease is myeloid sarcoma.