Based on previous studies, we speculated that circ-CBLB was contained in the exosomes isolated in this study, which was validated by RT-qPCR detection of circ-CBLB expression in RA-FLSs, exosomes, and macrophages.The m6A modification level of circ-CBLB in RA-FLSs was examined with MeRIP-qPCR, which showed that the m6A modification level of circ-CBLB was prominently increased after TNF-α stimulation, illustrating that the inflammatory microenvironment of RA promotes the m6A modification level of circ-CBLB. The gene discussed is TNF; the disease is rheumatoid arthritis.