The addition of GW4869 did not significantly change circ-CBLB expression in RA-FLSs but declined circ-CBLB expression in exosomes and macrophages of the RA-FLS + M0 and RA-FLS + M0 + TNF-α groups (Figures 3D-F). The gene discussed is CBLB; the disease is rheumatoid arthritis.