Compared to the RA-FLS + M0 + TNF-α group, the RA-FLS + M0 + TNF-α + pcDNA3.1-WTAP group had lower circ-CBLB expression, whilst the RA-FLS + M0 + TNF-α + si-WTAP group had higher circ-CBLB expression (Figure 6B). The gene discussed is CBLB; the disease is rheumatoid arthritis.