Circ-CBLB expression in RA-FLSs, exosomes, and macrophages was examined, which displayed that circ-CBLB expression in RA-FLSs, exosomes, and macrophages was substantially lower in the RA-FLS + M0 + TNF-α group than in the RA-FLS + M0 group (Figure 3A-C). This evidence concerns the gene CBLB and rheumatoid arthritis.