The results uncovered that the m6A modification level of circ-CBLB was decreased and the expression of circ-CBLB was increased in the RA-FLS + TNF-α + M0 + pcDNA3.1-NC + MUT-circ-CBLB group (the MUT group) versus the RA-FLS + TNF-α + M0 + pcDNA3.1-NC + WT-circ-CBLB group (the WT group) (Figures 8A, B). Here, TNF is linked to rheumatoid arthritis.