This transcriptomic study identified various differentially expressed genes, including Pik3cd, Pld1, Oprd1, Gab2, Abcc1, Ppp2r2b, Cers5, Bcl2, Rac2, Adora3, Sgpp2, and Sphk1. Changes in the expression of these genes may stimulate the progression of liver fibrosis by affecting cell proliferation, apoptosis, and signaling mechanisms. This evidence concerns the gene OPRD1 and Hepatic fibrosis.