Finally, even a small fraction of an intravenous drug administered as a test dose can potentially trigger fatal anaphylaxis in IgE-mediated reactions, making the use of this approach in general practice inherently risky [5].The EAACI and the American Academy of Allergy, Asthma, and Immunology (AAAAI) provide recommendations for skin testing only in suspected cases of antibiotic allergies. Here, IGHE is linked to anaphylaxis.