For instance, the reduction in the bioavailability of vascular-derived NO, together with an increase in the systemic proinflammatory condition in the settings of MetS, augmented TNF-α levels inducing the abnormal remodeling of the resistance blood vessels, a condition that was alleviated by the acute treatment with the antioxidant tempol (Brooks et al., 2015). Here, TNF is linked to metabolic syndrome.