CACNA1C and metabolic syndrome: Overall, a deeper understanding of the underlying molecular mechanisms in prediabetes and MetS that participate in altering the expression or the activity of the CaV1.2, the SERCA pump, the RyRs, and the BKCa channels in the vasculature, will help to identify early events in diabetic vasculopathy, and to design prompt therapeutical interventions to stop the progression of the disease.