Regarding the therapeutic perspective, the functions and associations of OPN4, along with the alterations caused by its SNPs, are valuable due to their connections to health issues such as Alzheimer’s disease, Parkinson’s disease (La Morgia et al., 2017, 2023) and autism spectrum disorder (Kercher et al., 2020). The gene discussed is OPN4; the disease is early-onset autosomal dominant Alzheimer disease.