Similarly, S2R ligands have been shown to exhibitdiverse clinicallyrelevant properties in dopaminergic transmission, microglia activation,and neuroprotection., Specifically, small moleculesthat bind S2R have had beneficial effects in Alzheimer’s disease,−, ,  neuropathic pain,−, ,  traumatic brain injury, Huntington’sdisease, and Parkinson’s disease, among others. Here, TMEM97 is linked to early-onset autosomal dominant Alzheimer disease.