The strongest evidence forthat specificity comes from experiments in neuroblastoma cells.,, In these contributions, the Gal-1binding to the cell surface is quantified by radioisotope I125 Gal-1 marking, or by Gal-1 visualization viafluorescently labeled antibodies. Theconcept of these experiments is a) to vary GM1 concentrationson the cell surface by using different cell lines or interfering withthe neuraminidase activity or b) blocking surface GM1 byantibodies or cholera toxin B subunit. The gene discussed is GAL; the disease is neuroblastoma.