This study reveals that GLSO significantly reduces the gray ground-glass opacities in lung images of mice with granulomatous pulmonary nodules, decreases the granuloma area, and lowers the levels of inflammatory mediators (IFN-β, IFN-γ, IL-1β, TNF-α) and chemokines (CCL2, CXCL10, CCL4, CXCL9), demonstrating its therapeutic potential for granulomatous pulmonary nodule. Here, CCL2 is linked to Granuloma.