Leishmaniasis is a disease that can evolve to a chronic status, capable of causing a variability of symptoms and signs that can be observed through clinical and laboratory tests, changes such as leukocytosis or leukopenia (by bone marrow exhaustion) are observed, as well as elevated levels of LDH, C-reactive protein, fibrinogen and normochromic anemia characteristic of chronic inflammation (Solano-Gallego et al., 2016). The gene discussed is CRP; the disease is anemia (phenotype).