A different heterozygous substitution, PLN c.73C>T, p. Arg25Cys, has been identified by multiple studies in patients presenting DCM and cardiac arrhythmias, HCM or Brugada syndrome patients with QRS duration (Behr et al., 2015; Liu et al., 2015; Lopes et al., 2015). Here, PLN is linked to chronic obstructive pulmonary disease.