For example, although PLN-Leu39Ter heterozygosity has been reported to lead to HCM, in the presence of three additional genetic variants in DCM/arrhythmia associated genes, a PLN-Leu39Ter heterozygote patient presented with DCM and sustained ventricular tachycardia (Sanoudou et al., 2015). This evidence concerns the gene PLN and familial dilated cardiomyopathy.