Moreover, PNS lowered the level of PKM2 in the nucleus of the activated microglia, concomitantly, blunted the hypoxia-inducible factor-1α (HIF-1α)/pyruvate kinase M2 (PKM2)/STAT3 pathway, which may underlie PNS’s inflammation-inhibitory effect in stroke (Gao et al., 2022). The gene discussed is PKM; the disease is Stroke.