NFKB1 and brain ischemia: Meanwhile, glycogen synthase kinase-3β, known as a serine/threonine kinase for controlling NF-κB signaling, dampens the activity of cAMP response element-binding protein (CREB) and increases the accumulation of intranuclear NF-κB induced by brain ischemia (Jover-Mengual et al., 2010).