IKBKB and neoplasm: The role of AT-rich interaction domain 1A (ARID1A), a component of the SWI/SNF chromatin remodeling complex, is also crucial; its loss, triggered by inflammation-induced IKKβ activation, leads to increased MDSC chemotaxis and enhances tumor progression through the IKKβ/ARID1A/NF-κB feedback loop (90).