IFNG and neoplasm: Of note, the anti-tumor immune response-related hallmark gene sets and KEGG pathways including inflammatory response, interferon alpha response, interferon gamma, antigen processing and presentation, cytokine-cytokine receptor interaction, natural killer cell medicated cytotoxicity, T cell receptor signaling pathway, were significantly enriched in the low methylation group (Figure 4B, FDR < 0.001).