In HCC cells, dysregulation of Gal-1 expression overactivated the FAK/PI3K/AKT and H-Ras/Raf/extracellular signal-regulated kinase (ERK) pathways and increased the phosphorylation of AKT, mTOR, and p70 kinases, as well as the expression of the αvβ3 integrin. This evidence concerns the gene MTOR and hepatocellular carcinoma.