LCSCs and cells that undergo EMT enhance the heterogeneity of cells within the tumor and have similar genetic characteristics, including elevated expression of surface glycoproteins of cell adhesion (CD44, CD133, CD13, CD24, CD90, EpCAM, and N-cadherin), keratin 19, aldehyde dehydrogenase 1A1, and transcription factors (SNAI1, SLUG, TWIST1, ZEB1, and ZEB2) [188–190]. Here, TWIST1 is linked to neoplasm.