LGALS1 and hepatocellular carcinoma: In HCC cells, dysregulation of Gal-1 expression overactivated the FAK/PI3K/AKT and H-Ras/Raf/extracellular signal-regulated kinase (ERK) pathways and increased the phosphorylation of AKT, mTOR, and p70 kinases, as well as the expression of the αvβ3 integrin.