RELN and memory impairment: Reelin protects the brain from Aβ-induced synaptic dysfunction and memory impairment (Lane-Donovan et al., 2015) while linking Aβ and tau phosphorylation dysregulation that Aβ induces impaired Reelin signaling, resulting in a reduced ability of Reelin to down-regulate tau phosphorylation via GSK3β (Cuchillo-Ibáñez et al., 2013).